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Over the last few years, biotechnology has developed into an important innovation and business sector for Germany. With its first-class scientific landscape, numerous internationally successful SMEs and a strong, globally active chemical and pharmaceuticals industry, NRW is a major contributor to this development. Some 300 life science firms, of which approx. 170 specialize in biotechnology, mark the state as one of Europe's leading innovation centers. Major international players based in NRW include Qiagen and Miltenyi Biotech as well as many dynamically growing companies such as Artes Biotechnologie, Bitop, Dasgip or Protagen.